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Antibodies
Anti-RRM2 antibody [1E1]
Anti-RRM2 antibody [1E1] from Abcam
Be the first to write a review!
Citations:
(40)
Supplier Page
Supplier Page from
Abcam for
Anti-RRM2 antibody [1E1]
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-RRM2 antibody [1E1]
Company
Abcam
Price
Supplier Page
View Company Product Page
Catalog Number
ab57653
Antibody Type
Primary
Quantity
100 UG
Applications
Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Host
Mouse, Nude mouse
Clonality
Monoclonal
Isotype
IgG1
Conjugate/Tag
Unconjugated
Concentration
0.5 mg/ml
Clone
10
Gene Name
rrm2
Reactivity
Human
Target
RRM2
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (40)
(1)
Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus
Cancers (Basel)
June 25, 2023
Quinn T. Storozynsky, Xuefei Han, Shae Komant, Kate C. Agopsowicz, Kyle G. Potts, Armin M. Gamper, Roseline Godbout, David H. Evans, Mary M. Hitt
anti-
p21
(
1:1000
;
ab109520
,
Abcam
, Cambridge, UK), anti-TK1 (
1:500
;
ab59271
,
Abcam
), anti-RRM2 (
1:500
;
ab57653
,
Abcam
),
anti-p53R2
(
1:1000
;
ab8105
[
Abcam
]), anti-β-tubulin (
1:1000
;
2146
,
Cell Signaling Technologies
,
(2)
MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2
Annals of Translational Medicine
December 1, 2022
Xiaowen Cao, Fangsu Xue, Haoyu Chen, Lu Shen, Xiaosa Yuan, Yunchi Yu, Ying Zong, Lou Zhong, Fang Huang
All-in-one RT SuperMix Perfect for
qPCR
were purchased from Nanjing Vazyme Biotech Co., Ltd. The RRM2 (
ab57653
) and β-actin (
ab8226
) antibodies were purchased from
Abcam
(USA), and the
goat
anti-
mouse
secondary
(3)
LncRNA HOTAIR facilitates proliferation and represses apoptosis of retinoblastoma cells through the miR-20b-5p/RRM2/PI3K/AKT axis
Orphanet Journal of Rare Diseases
December 1, 2022
Ke Fu, Ke Zhang, Xiaoyu Zhang
MA, USA), Cleaved Caspase-3 (20 µg/mL,
ab32042
,
Abcam
), Bcl-2 (1/500,
ab692
,
Abcam
), RRM2 (1 µg/mL,
ab57653
,
Abcam
, Cambridge, MA, USA), AKT (1/500,
ab8805
,
Abcam
), phosphorylated AKT (p-AKT, 1/500,
ab38449
,
(4)
MiR ‐200c‐3p and miR ‐485‐5p overexpression elevates cisplatin sensitivity and suppresses the malignant phenotypes of non–small cell lung cancer cells through targeting RRM2
Thoracic Cancer
July 1, 2022
Ying Liu, Yong Zhang, Qiubo Li, Ruiqi Xu, Nian Huang
(BSA) to seal the non‐specific binding sites and probed with primary antibodies, containing anti‐RRM2 (
ab57653
) (
Abcam
) and anti‐GAPDH (
ab9485
) (
Abcam
). The
immunoblots
were then probed with horseradish peroxidase
(5)
Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)
Bioengineered
May 24, 2022
Siwei Li, Heng Zhang, Yunping Jiao, Xiao Song, Lei Wei, Xing Liu
Bcl-2-associated X (Bax;
Abcam
,
ab32503
,
1:1000
), cleaved-caspase-3 (
Abcam
,
ab2302
,
1:1000
), RRM2 (
Abcam
,
ab57653
,
1:1000
), and GAPDH (
Abcam
,
ab181602
,
1:3000
). Goat anti-rabbit/mouse IgG H&L (HRP) secondary antibody
(6)
Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung Adenocarcinoma
Frontiers in oncology
January 1, 2022
Song X, Wu L, Wang G, Liu B, Zhu W.
MIF (
ab65869
,
Abcam
, Cambridge, MA, USA),
PANX1
(
12595-1-AP
,
Proteintech
, Wuhan, China), and RRM2 (
ab57653
,
Abcam
). The primary antibody of EGLN1 was diluted at
1:100
, others were diluted at
1:200
and incubated
(7)
Anti-Tumor Effect of Apatinib and Relevant Mechanisms in Liposarcoma
Frontiers in Oncology
November 18, 2021
Lixuan Cui et al.
in the subsequent experiments. Anti-CD34 (No.
ab81289
), anti-RRM2(No.
ab108995
), and anti-
TYMS
(No.
ab57653
) were obtained from
Abcam
, Cambridge, UK. Anti-
STAT3
(No.
4904T
), anti-p-STAT3(No.
9145T
),anti-
AKT
(No.
4691T
),anti-p-AKT(No.
4060T
),anti-
mTOR
(No.
2983T
),anti-p-mTOR(No.
5536T
),anti-PD-L1(No.
13684S
),anti-PI3K(No.
(8)
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment
Cancers (Basel)
August 20, 2021
Christina Bothou, Ashish Sharma, Adrian Oo, Baek Kim, Pal Perge, Peter Igaz, Cristina L. Ronchi, Igor Shapiro, Constanze Hantel
conducted according to the protocol
for immunohistochemistry
. Primary anti-
RRM2
mouse
MAB was used (#
ab57653
,
Abcam
, Cambridge, UK) at a 2.5 mg/mL dilution overnight at 4 °C. The secondary antibody was used at
(9)
Proteomic Reveals Reasons for Acquired Drug Resistance in Lung Cancer Derived Brain Metastasis Based on a Newly Established Multi-Organ Microfluidic Chip Model
Frontiers in Bioengineering and Biotechnology
December 22, 2020
Mingxin Xu, Yingyan Wang, Wenzhe Duan, Shengkai Xia, Song Wei, Wenwen Liu, Qi Wang
with primary antibodies against
GPX4
(
1:1,000
dilution;
ab125066
,
Abcam
, UK), RRM2 (
1:1,000
dilution;
ab57653
,
Abcam
, UK),
GCLC
(
1:1,000
dilution;
ab190685
,
Abcam
, UK),
GPX1
(
1:1,000
dilution;
ab108427
,
Abcam
,
(10)
RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
Cancer cell international
December 7, 2020
Yang Y, Lin J, Guo S, Xue X, Wang Y, Qiu S, Cui J, Ma L, Zhang X, Wang J.
Technology (
CST
), Boston, MA, USA, #
5174
or #
51332
), anti-
RRM2
(
Abcam
, Hong Kong, China, #
ab172476
and #
ab57653
), anti-
CBS
(
Abcam
, #
ab140600
), anti-
CTH
(
Abcam
, #
ab189916
), anti-
SHMT2
(
Abcam
, #
ab180786
), anti-
GPX4
(11)
LncRNA TTN-AS1 Regulates miR-524-5p and RRM2 to Promote Breast Cancer Progression
OncoTargets and Therapy
May 27, 2020
Hui Feng, Qi Wang, Wenjing Xiao, Biyuan Zhang, Yonglong Jin, Haijun Lu
MA, USA) and blocked with 5% skim milk for 1 h. After incubated with primary antibodies anti-RRM2 (
ab57653
,
Abcam
,
1:1000
), antiSurvivin antibody (
ab76424
,
Abcam
,
1:1000
) and antiGAPDH (
ab8245
,
Abcam
,
1:1000
)
(12)
RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling
Oncology letters
April 1, 2020
Zhuang S, Li L, Zang Y, Li G, Wang F.
(
Corning
, Inc.). All protocols were Antibodies.
Mouse
monoclonal antibodies to
human
RRM2
(cat. no.
ab57653
) and rabbit monoclonal antibodies to
human
MMP‑2 antibodies (cat. no.
ab92536
) were purchased from
Abcam
.
(13)
Knockdown of lncRNA KCNQ1OT1 inhibits glioma progression by regulating miR-338-3p/RRM2
Open Life Sciences
March 12, 2020
Zhangxing Yin, Liqing Liao, Sheng Mao, Ying Liu, Tao Xie, Hua Yu, Wenxu Zhao
western blocking buffer (Beyotime) and then incubated with the following primary antibodies against RRM2 (
ab57653
,
1:100
dilution,
Abcam
, Cambridge, MA, USA),
PCNA
(
ab152112
,
1:3000
dilution,
Abcam
), KCNQ1OT1 regulates
(14)
Cyclin F is involved in response to cisplatin treatment in melanoma cell lines
Oncology reports
March 1, 2020
Krajewski A, Gagat M, Żuryń A, Hałas-Wiśniewska M, Grzanka D, Grzanka A.
antibodies were used: Cyclin F (cat. no.
sc-515207
;
1:100
,
Santa Cruz Biotechnology Inc
.). RRM2 (cat. no.
ab57653
;
1:200
,
Abcam
),
p53
(Pab 240; cat. no.
13-4100
;
1:100
), p-ATR (cat. no.
720107
;
1:200
), p-H2.AX (cat.
(15)
Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance
OncoTargets and therapy
January 1, 2020
Zhang S, Yan L, Cui C, Wang Z, Wu J, Lv A, Zhao M, Dong B, Zhang W, Guan X,
et al
.
Beijing, China) was used to block the slices. The slices were incubated with RRM2 antibody (
1:800
,
ab57653
,
Abcam
, Cambridge, MA, USA) and secondary antibody working fluid (PV-6000, Beijing Zhongshan Golden
(16)
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis
Cell Chemical Biology
January 1, 2020
Marcus J.C. Long, Yi Zhao, Yimon Aye
60073-1-Ig
(Ms),
Proteintech
,
1:2000
(WB),
1:200
(IF),
1:300
(PLA for both HeLa and U2OS cells)]; RNR-β [
AB57653
(Ms),
AbCam
,
1:1000
(WB),
1:200
(IF)]; BrdU [NA61, Calbiochem,
1:1000
(
Clone
MoBu-1, DPA, selective
(17)
Cyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell Line
Cancer management and research
January 1, 2020
Krajewski A, Gagat M, Mikołajczyk K, Izdebska M, Żuryń A, Grzanka A.
(
ThermoFisher
, M1-154), cyclin B (ThermoFisher, MA5-14,319), cyclin D (
Sigma-Aldrich
,
SAB4502603
), RRM2 (
Abcam
,
ab57653
),
p53
(
ThermoFisher
, Pab 240),
NFkB p65
(
ThermoFisher
,
33–9900
), vimentin –
immunofluorescence
(
Abcam
,
(18)
Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis
Cancer Management and Research
December 23, 2019
Hongying Ma, Jian Qu, Jian Luo, Tingting Qi, Huanmiao Tan, Zhaohui Jiang, Haiwen Zhang, Qiang Qu
(19)
RRM2 Regulated By LINC00667/miR-143-3p Signal Is Responsible For Non-Small Cell Lung Cancer Cell Progression
OncoTargets and Therapy
November 20, 2019
Yanbing Yang, Sensen Li, Juan Cao, Yaojun Li, Haiying Hu, Zhuyu Wu
at room temperature and incubated with primary antibodies at 4°C overnight, including RRM2 (
1:1000
,
ab57653
,
Abcam
), Cyclin A1 (
1:1000
,
ab53699
,
Abcam
), Cyclin B1 (
1:1000
,
ab72
,
Abcam
), CDK2 (
1:1000
, ab32174,
(20)
Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib‑based therapy
Oncology Reports
June 11, 2019
Chunshui Liu, Yuying Li, Ruiping Hu, Wei Han, Sujun Gao
TBST at 37°C for 1 h and incubated with primary antibodies including: RRM2 (dilution
1:1,000
, cat. no.
ab57653
;
Abcam
, Shanghai, China), Bcl-2 (dilution
1:1,000
; cat. no.
ab59348
;
Abcam
), Bax (dilution
1:1,000
;
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Anti-RRM2 antibody [1E1] from Abcam
Supplier Page
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